Red blood cell blood group A antigen level affects the ability of heparin and PfEMP1 antibodies to disrupt Plasmodium falciparum rosettes.

ABSTRACT:

Background

The histo-blood group ABO system has been associated with adverse outcomes in COVID-19, thromboembolic diseases and Plasmodium falciparum malaria. An integral part of the severe malaria pathogenesis is rosetting, the adherence of parasite infected red blood cells (RBCs) to uninfected RBCs. Rosetting is influenced by the host's ABO blood group (Bg) and rosettes formed in BgA have previously been shown to be more resilient to disruption by heparin and shield the parasite derived surface antigens from antibodies. However, data on rosetting in weak BgA subgroups is scarce and based on investigations of relatively few donors.

Methods

An improved high-throughput flow cytometric assay was employed to investigate rosetting characteristics in an extensive panel of RBC dono

SUBMITTER: Hedberg P 

PROVIDER: S-EPMC8600353 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature