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Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides.

ABSTRACT: Enzyme-instructed self-assembly (EISA) and hydrogelation is a versatile approach for generating soft materials. Most of the substrates for alkaline phosphatase catalysed EISA utilize phosphotyrosine (_pTyr) as the enzymatic trigger for EISA and hydrogelation. Here we show the first example of phosphonaphthyl (_pNP) and phosphobiphenyl (_pBP) motifs acting as faster enzymatic triggers than phosphotyrosine for EISA and hydrogelation. This work illustrates novel enzyme triggers for rapid enzymatic self-assembly and hydrogelation.

SUBMITTER: Yi M

PROVIDER: S-EPMC8600407 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides.

Yi Meihui M Guo Jiaqi J He Hongjian H Tan Weiyi W Harmon Nya N Ghebreyessus Kesete K Xu Bing B

Soft matter 20211006 38

Enzyme-instructed self-assembly (EISA) and hydrogelation is a versatile approach for generating soft materials. Most of the substrates for alkaline phosphatase catalysed EISA utilize phosphotyrosine (pTyr) as the enzymatic trigger for EISA and hydrogelation. Here we show the first example of phosphonaphthyl (pNP) and phosphobiphenyl (pBP) motifs acting as faster enzymatic triggers than phosphotyrosine for EISA and hydrogelation. This work illustrates novel enzyme ...[more]

PMID: 34545895

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