Gene Signatures and Cancer-Immune Phenotypes Based on m⁶A Regulators in Breast Cancer.

ABSTRACT: The N⁶-methyladenosine (m⁶A) has been considered as a new layer of epitranscriptomic regulation on mRNA processing, stability, and translation. However, potential roles of m⁶A RNA methylation modification in tumor immune microenvironment (TIME) of breast cancer are yet fully understood. In this study, we comprehensively evaluated the genetic variations and transcript expressions of 15 m⁶A regulators in 1,079 breast cancer samples from the Cancer Genome Atlas (TCGA) database. We validated major regulators had significantly differential mRNA and protein expression in tumor tissue compared to normal tissues from 39 pairs of clinical breast cancer samples with different molecular subtypes, and especially high expression of m⁶A readers YTHD

SUBMITTER: Zhao G 

PROVIDER: S-EPMC8600443 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature