Ontology highlight
ABSTRACT:
SUBMITTER: Sirucek L
PROVIDER: S-EPMC8600541 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Sirucek Laura L Price Rebecca Christine RC Gandhi Wiebke W Hoeppli Marie-Eve ME Fahey Emma E Qu Annie A Becker Susanne S Schweinhardt Petra P
Pain 20211201 12
Endogenous opioids mediate the pleasurable responses to positively reinforcing stimuli such as palatable food. Yet, the reduction or omission of a negative experience can also be rewarding (negative reinforcement). As such, pain relief leads to negative reinforcement and evokes a pleasant feeling in humans. Although it has been shown that the feeling of pleasure associated with positive reinforcement is at least partly mediated through endogenous opioids, it is currently unknown whether similar ...[more]