Anticoagulant prescribing for atrial fibrillation and risk of incident dementia.

ABSTRACT:

Objective

The aim of this study was to investigate the association between oral anticoagulant type (direct oral anticoagulants (DOACs) vs vitamin K antagonists (VKAs)) and incident dementia or mild cognitive impairment (MCI) among patients with newly diagnosed atrial fibrillation (AF).

Methods

Using linked electronic health record (EHR) data from the Clinical Practice Research Datalink in the UK, we conducted a historical cohort study among first-time oral anticoagulant users with incident non-valvular AF diagnosed from 2012 to 2018. We compared the incidence of (1) clinically coded dementia and (2) MCI between patients prescribed VKAs and DOACs using Cox proportional hazards regression models, with age as the underlying timescale, accounting for calendar time and time on tr

SUBMITTER: Cadogan SL 

PROVIDER: S-EPMC8600601 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature