Preconception leukocyte telomere length and pregnancy outcomes among women with demonstrated fecundity.

ABSTRACT:

Study question

Is preconception leukocyte telomere length associated with fecundability, pregnancy loss and live birth among women attempting natural conception with a history of 1-2 prior pregnancy losses?

Summary answer

Preconception leukocyte telomere length is not associated with fecundability, pregnancy loss or live birth.

What is known already

As women increasingly delay childbearing, accessible preconception biomarkers to predict pregnancy outcomes among women seeking natural conception could improve preconception counseling. Findings of small case-control or cross-sectional studies suggest that telomere attrition is associated with adverse pregnancy outcomes among women undergoing fertility treatment, but prospective studies in non-clinical populations are lac

SUBMITTER: Purdue-Smithe AC 

PROVIDER: S-EPMC8600655 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature