Development and external validation of a nomogram for neurosyphilis diagnosis among non-HIV patients: a cross-sectional study.

ABSTRACT:

Background

The diagnosis of neurosyphilis is challenging due to the requirement of a lumbar puncture and cerebrospinal fluid (CSF) laboratory tests. Therefore, a convenient diagnostic nomogram for neurosyphilis is warranted. This study aimed to construct diagnostic models for diagnosing neurosyphilis.

Methods

This cross-sectional study included data of two patient cohorts from Western China Hospital of Sichuan University between September 2015 and April 2021 and Shangjin Hospital between September 2019 and April 2021 as the development cohort and the external validation cohort, respectively. A diagnostic model using logistic regression analysis was constructed to readily provide the probability of diagnosis at point of care and presented as a nomogram. The clinical usefulnes

SUBMITTER: Ge W 

PROVIDER: S-EPMC8600785 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature