LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are derived from bone marrow progenitor cells commonly, which is a heterogeneous cell group composed of immature granulocytes, dendritic cells, macrophages and early undifferentiated bone marrow precursor cells. Its differentiation and immunosuppressive function are regulated by complex network signals, but the specific regulation mechanisms are not yet fully understood. In this study, we found that in mouse of Lewis lung cancer xenograft, long non-coding RNA Snhg6 (lncRNA Snhg6) was highly expressed in tumor-derived MDSCs compared with spleen-derived MDSCs. LncRNA Snhg6 facilitated the differentiation of CD11b⁺ Ly6G^- Ly6C^high monocytic MDSCs (Mo-MDSCs) rather than CD11b⁺ Ly6G⁺ Ly6C^low

SUBMITTER: Lu W 

PROVIDER: S-EPMC8600792 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature