Explore association of genes in PDL1/PD1 pathway to radiotherapy survival benefit based on interaction model strategy.

ABSTRACT:

Purpose

To explore the association of genes in "PD-L1 expression and PD-1 check point pathway in cancer" to radiotherapy survival benefit.

Methods and materials

Gene expression data and clinical information of cancers were downloaded from TCGA. Radiotherapy survival benefit was defined based on interaction model. Fast backward multivariate Cox regression was performed using stacking multiple interpolation data to identify radio-sensitive (RS) genes.

Results

Among the 73 genes in PD-L1/PD-1 pathway, we identified 24 RS genes in BRCA data set, 25 RS genes in STAD data set and 20 RS genes in HNSC data set, with some crossover genes. Theoretically, there are two types of RS genes. The expression level of Type I RS genes did not affect patients' overall survival (OS), but

SUBMITTER: Shen J 

PROVIDER: S-EPMC8600865 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature