Examination of lipid profiles in abdominal fascial healing using MALDI-TOF to identify potential therapeutic targets.

ABSTRACT:

Background

Failure of fascial healing in the abdominal wall can result in incisional hernia, which is one of the most common complications after laparotomy. Understanding the molecular healing process of abdominal fascia may provide lipid markers of incisional hernia or therapeutic targets that allow prevention or treatment of incisional hernias.

Purpose

This study aims to investigate temporal and in situ changes of lipids during the normal healing process of abdominal fascia in the first postoperative week.

Methods

Open hemicolectomy was performed in a total of 35 Wistar rats. The midline fascia was closed identically for all rats using a single continuous suturing technique. These animals were sacrificed with equal numbers (n = 5) at each of 7-time points (6, 12, 24

SUBMITTER: Liu H 

PROVIDER: S-EPMC8600998 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature