A proposal for score assignment to characterize biological processes from mass spectral analysis of serum.

ABSTRACT:

Introduction

Most diseases involve a complex interplay between multiple biological processes at the cellular, tissue, organ, and systemic levels. Clinical tests and biomarkers based on the measurement of a single or few analytes may not be able to capture the complexity of a patient's disease. Novel approaches for comprehensively assessing biological processes from easily obtained samples could help in the monitoring, treatment, and understanding of many conditions.

Objectives

We propose a method of creating scores associated with specific biological processes from mass spectral analysis of serum samples.

Methods

A score for a process of interest is created by: (i) identifying mass spectral features associated with the process using set enrichment analysis methods, an

SUBMITTER: Roder J 

PROVIDER: S-EPMC8601010 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature