Clinical Correlation of Multiple Sclerosis Immunopathologic Subtypes.

ABSTRACT:

Background and objectives

The goal of this work was to compare clinical characteristics across immunopathologic subtypes of patients with multiple sclerosis.

Methods

Immunopathologic subtyping was performed on specimens from 547 patients with biopsy- or autopsy-confirmed CNS demyelination.

Results

The frequency of immunopathologic subtypes was 23% for pattern I, 56% for pattern II, and 22% for pattern III. Immunopatterns were similar in terms of age at autopsy/biopsy (median age 41 years, range 4-83 years, p = 0.16) and proportion female (54%, p = 0.71). Median follow-up after symptom onset was 2.3 years (range 0-38 years). In addition to being overrepresented among autopsy cases (45% vs 19% in biopsy cohort, p < 0.001), index attack-related disab

SUBMITTER: Tobin WO 

PROVIDER: S-EPMC8601208 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature