Common X-Chromosome Variants Are Associated with Parkinson Disease Risk.

ABSTRACT:

Objective

The objective of this study was to identify genetic variants on the X-chromosome associated with Parkinson disease (PD) risk.

Methods

We performed an X-chromosome-wide association study (XWAS) of PD risk by meta-analyzing results from sex-stratified analyses. To avoid spurious associations, we designed a specific harmonization pipeline for the X-chromosome and focused on a European ancestry sample. We included 11,142 cases, 280,164 controls, and 5,379 proxy cases, based on parental history of PD. Additionally, we tested the association of significant variants with (1) PD risk in an independent replication with 1,561 cases and 2,465 controls and (2) putamen volume in 33,360 individuals from the UK Biobank.

Results

In the discovery meta-analysis, we identified

SUBMITTER: Le Guen Y 

PROVIDER: S-EPMC8601399 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature