Fibrosis Regression After Eradication of Hepatitis C Virus: From Bench to Bedside.

ABSTRACT: Hepatitis C virus (HCV) infection and its complications have been the major cause of cirrhosis and its complications for several decades in the Western world. Until recently, treatment for HCV with interferon-based regimens was associated with moderate success but was difficult to tolerate. More recently, however, an arsenal of novel and highly effective direct-acting antiviral (DAA) drugs has transformed the landscape by curing HCV in a broad range of patients, including those with established advanced fibrosis, cirrhosis, comorbidities, and even those with complications of cirrhosis. Fibrosis is a dynamic process comprising both extracellular matrix deposition, as well as its degradation. With almost universal sustained virologic response (SVR) (ie, elimination of HCV), it is timely to e

SUBMITTER: Rockey DC 

PROVIDER: S-EPMC8601597 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature