From spikes to intercellular waves: Tuning intercellular calcium signaling dynamics modulates organ size control.

ABSTRACT: Information flow within and between cells depends significantly on calcium (Ca2+) signaling dynamics. However, the biophysical mechanisms that govern emergent patterns of Ca2+ signaling dynamics at the organ level remain elusive. Recent experimental studies in developing Drosophila wing imaginal discs demonstrate the emergence of four distinct patterns of Ca2+ activity: Ca2+ spikes, intercellular Ca2+ transients, tissue-level Ca2+ waves, and a global "fluttering" state. Here, we used a combination of computational modeling and experimental approaches to identify two different populations of cells within tissues that are connected by gap junction proteins. We term these two subpopulations "initiator cells," defined by elevated levels of Phospholipase C (PLC) activity, and "standby cells," w

SUBMITTER: Soundarrajan DK 

PROVIDER: S-EPMC8601605 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature