Atypically larger variability of resource allocation accounts for visual working memory deficits in schizophrenia.

ABSTRACT: Working memory (WM) deficits have been widely documented in schizophrenia (SZ), and almost all existing studies attributed the deficits to decreased capacity as compared to healthy control (HC) subjects. Recent developments in WM research suggest that other components, such as precision, also mediate behavioral performance. It remains unclear how different WM components jointly contribute to deficits in schizophrenia. We measured the performance of 60 SZ (31 females) and 61 HC (29 females) in a classical delay-estimation visual working memory (VWM) task and evaluated several influential computational models proposed in basic science of VWM to disentangle the effect of various memory components. We show that the model assuming variable precision (VP) across items and trials is the best mode

SUBMITTER: Zhao YJ 

PROVIDER: S-EPMC8601612 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature