Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.

ABSTRACT: Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a

SUBMITTER: Montero BK 

PROVIDER: S-EPMC8601626 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature