Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota.

ABSTRACT: Microbiota acquired during labor and through the first days of life contributes to the newborn's immune maturation and development. Mother provides probiotics and prebiotics factors through colostrum and maternal milk to shape the first neonatal microbiota. Previous works have reported that immunoglobulin A (IgA) secreted in colostrum is coating a fraction of maternal microbiota. Thus, to better characterize this IgA-microbiota association, we used flow cytometry coupled with 16S rRNA gene sequencing (IgA-Seq) in human colostrum and neonatal feces. We identified IgA bound bacteria (IgA+) and characterized their diversity and composition shared in colostrum fractions and neonatal fecal bacteria. We found that IgA2 is mainly associated with Bifidobacterium, Pseudomonas, Lactobacill

SUBMITTER: Sanchez-Salguero E 

PROVIDER: S-EPMC8601722 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature