¹¹C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography- computed tomography.

ABSTRACT: Identification of primary tumors and metastasis sites is an essential step in cancer diagnostics and the following treatment. Positron emission tomography-computed tomography (PET/CT) is one of the most reliable methods for scanning the whole organism for malignancies. In this work, we synthesized an ¹¹C-labeled oligonucleotide primer and hybridized it to an anti-cancer DNA aptamer. The ¹¹C-aptamer was applied for in vivo imaging of Ehrlich ascites carcinoma and its metastases in mice using PET/CT. The imaging experiments with the ¹¹C-aptamer determined very small primary and secondary tumors of 3 mm² and less. We also compared ¹¹C imaging with the standard radiotracer, 2-deoxy-2-[fluorine-18]fluoro-D-glucose (¹⁸F-FDG

SUBMITTER: Ozerskaya AV 

PROVIDER: S-EPMC8601970 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature