Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer.

ABSTRACT:

Background

Previous study implicated that genes of matrix metalloproteinase (MMP) family play an important role in tumor invasion, neoangiogenesis, and metastasis. However, the diverse expression patterns and prognostic values of 24 MMPs in colorectal cancer are yet to be analyzed.

Methods

In this study, by integrating public database and our data, we first investigated the expression levels and protein levels of MMPs in patients with colorectal cancer. Then, by using TCGA and GEO datasets, we evaluated the association of MMPs with clinicopathological parameters and prognosis of colorectal cancer. Finally, by using the cBioPortal online tool, we analyzed the alterations of MMPs and did the network and pathway analyses for MMPs and their nearby genes.

Results

We found

SUBMITTER: Yu J 

PROVIDER: S-EPMC8602079 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature