Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer.

ABSTRACT:

Purpose

To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).

Materials and methods

We analyzed data from 1105 patients with MIBC. Patients age was evaluated as continuous variable and stratified in quartiles. Pathologic objective response (pOR; ypT0-Ta-Tis-T1N0) and pathologic complete response (pCR; ypT0N0), as well survival outcomes were assessed. We used data of 395 patients from The Cancer Genome Atlas (TCGA) to investigate the prevalence of TCGA molecular subtypes and DNA damage repair (DDR) gene alterations according to patient age.

Results

pOR was achieved in 40% of patients. There was no difference in distribution of pOR or pCR between age quartiles. On univariable logistic

SUBMITTER: D'Andrea D 

PROVIDER: S-EPMC8602146 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature