Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets.

ABSTRACT: Lorcaserin is a serotonergic agonist specific to the 5-hydroxytryptamine 2c receptor (5-HT_2CR) that is FDA approved for the long-term management of obesity with or without at least one weight-related comorbidity. Lorcaserin can restrain patients' appetite and improve insulin sensitivity and hyperinsulinemia mainly through activating 5-HT_2CR in the hypothalamus. It is known that the mCPP, a kind of 5-HT_2CR agonist, decreases plasma insulin concentration in mice and previous research in our laboratory found that mCPP inhibited glucose-stimulated insulin secretion (GSIS) by activating 5-HT_2CR on the β cells. However, the effect of lorcaserin on GSIS of pancreatic β cell has not been studied so far. The present study found that 5-HT_2CR was

SUBMITTER: Jing M 

PROVIDER: S-EPMC8602196 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature