Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas.

ABSTRACT: Aberrant reprogramming of metabolism has been considered a hallmark in various malignant tumors. The metabolic changes of amino acid not only have dramatic effects in cancer cells but also influence their immune-microenvironment in gliomas. However, the features of the amino acid metabolism-related and immune-associated gene set have not been systematically described. The expression level of mRNA was obtained from The Cancer Genome Atlas database and the Chinese Glioma Genome Atlas database, which were used as training set and validation set, respectively. Different bioinformatics and statistical methods were combined to construct a robust amino metabolism-related and immune-associated risk signature for distinguishing prognosis and clinical pathology features. Constructing the nomogram en

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8602207 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature