Metabolic characterization and metabolism-score of tumor to predict the prognosis in prostate cancer.

ABSTRACT: Tumor metabolism patterns have been reported to be associated with the prognosis of many cancers. However, the metabolic mechanisms underlying prostate cancer (PCa) remain unknown. This study aimed to explore the metabolic characteristics of PCa. First, we downloaded mRNA expression data and clinical information of PCa samples from multiple databases and quantified the metabolic pathway activity level using single-sample gene set enrichment analysis (ssGSEA). Through unsupervised clustering and principal component analyses, we explored metabolic characteristics and constructed a metabolic score for PCa. Then, we independently validated the prognostic value of our metabolic score and the nomogram based on the metabolic score in multiple databases. Next, we found the metabolic score to be cl

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8602249 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature