Temporal variability in quantitative human gut microbiome profiles and implications for clinical research.

ABSTRACT: While clinical gut microbiota research is ever-expanding, extending reference knowledge of healthy between- and within-subject gut microbiota variation and its drivers remains essential; in particular, temporal variability is under-explored, and a comparison with cross-sectional variation is missing. Here, we perform daily quantitative microbiome profiling on 713 fecal samples from 20 Belgian women over six weeks, combined with extensive anthropometric measurements, blood panels, dietary data, and stool characteristics. We show substantial temporal variation for most major gut genera; we find that for 78% of microbial genera, day-to-day absolute abundance variation is substantially larger within than between individuals, with up to 100-fold shifts over the study period. Diversity, and espe

SUBMITTER: Vandeputte D 

PROVIDER: S-EPMC8602282 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature