Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma.

ABSTRACT: Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically unmet need for predictive biomarkers of response. Herein, we perform CODEX multiplexed tissue imaging and RNA sequencing on 70 tumor regions from 14 advanced CTCL patients enrolled in a pembrolizumab clinical trial (NCT02243579). We find no differences in the frequencies of immune or tumor cells between responders and non-responders. Instead, we identify topographical differences between effector PD-1⁺ CD4⁺ T cells, tumor cells, and immunosuppressive Tregs, from which we derive a spatial biomarker, termed the SpatialScore, that correlates strongly with pembrolizumab response in CTCL. The Spa

SUBMITTER: Phillips D 

PROVIDER: S-EPMC8602403 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature