IPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disease with unknown cause in the majority of patients, who are therefore considered "idiopathic" (IPD). PD predominantly affects dopaminergic neurons in the substantia nigra pars compacta (SNpc), yet the pathology is not limited to this cell type. Advancing age is considered the main risk factor for the development of IPD and greatly influences the function of microglia, the immune cells of the brain. With increasing age, microglia become dysfunctional and release pro-inflammatory factors into the extracellular space, which promote neuronal cell death. Accordingly, neuroinflammation has also been described as a feature of PD. So far, studies exploring inflammatory pathways in IPD patient samples have primarily focused on blood-derived immune

SUBMITTER: Badanjak K 

PROVIDER: S-EPMC8602578 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature