Exploring novel capping framework: high substituent pyridine-hydroxamic acid derivatives as potential antiproliferative agents.

ABSTRACT:

Purpose

Histone deacetylases (HDACs) play a vital role in the epigenetic regulation of gene expression due to their overexpression in several cancer forms. Therefore, these enzymes are considered as a potential anticancer drug target. Different synthetic and natural structures have been studied as HDACs inhibitors; based on available structural design information, the capping group is important for the biological activity due to the different interactions in the active site entrance. The present study aimed to analyze high substituted pyridine as a capping group, which included carrying out the synthesis, antiproliferative activity analysis, and docking studies of these novel compounds.

Methods

To achieve the synthesis of these derivatives, four reaction steps were performed

SUBMITTER: Hernandez-Borja F 

PROVIDER: S-EPMC8602590 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature