Hydroxy-Safflower Yellow A Alleviates Osteoporosis in Ovariectomized Rat Model by Inhibiting Carbonic Anhydrase 2 Activity.

ABSTRACT: Background: To investigate the therapeutic effect of Hydroxy-safflower yellow A (HSYA) on rat's osteoporosis and explore its potential mechanism of action. Methods: Bilateral ovariectomized female rats (OVX) were used to establish a postmenopausal rat model of osteoporosis. HSYA was given as an intervention, and estradiol was used as a positive control. The levels of serum alkaline phosphatase (ALP), calcium ion (Ca²⁺), and inorganic phosphorus (IP) were used to detect bone loss. Three months after modeling, the rats were sacrificed and the rat's ovaries, kidneys, tibia, and femur were used to calculate the organ index. The bone marrow of the femur of the rats was stained with Giemsa staining. The femur strength of rats was measured by INSTRON. The degree of osteop

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8602693 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature