Ferumoxytol magnetic resonance imaging detects joint and pleural infiltration of bone sarcomas in pediatric and young adult patients.

ABSTRACT:

Background

The diagnosis of joint infiltration by a malignant bone tumor affects surgical management. The specificity of standard magnetic resonance imaging (MRI) for diagnosing joint infiltration is limited. During our MRI evaluations with ferumoxytol nanoparticles of pediatric and young adult patients with bone sarcomas, we observed a surprising marked T1 enhancement of joint and pleural effusions in some patients but not in others.

Objective

To evaluate if nanoparticle extravasation differed between joints and pleura with and without tumor infiltration.

Materials and methods

We retrospectively identified 15 pediatric and young adult patients (mean age: 16±4 years) with bone sarcomas who underwent 18 MRI scans at 1 h (n=7) or 24 h (n=11) after intravenous ferumoxyto

SUBMITTER: Theruvath AJ 

PROVIDER: S-EPMC8602726 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature