Eplet mismatches associated with de novo donor-specific HLA antibody in pediatric kidney transplant recipients.

ABSTRACT:

Background

Optimizing amino acid (eplet) histocompatibility at first transplant decreases the risk of de novo donor-specific antibody (dnDSA) development and may improve long-term graft survival in pediatric kidney transplant recipients (KTR). We performed a retrospective analysis of pediatric KTR and their respective donors to identify eplets most commonly associated with dnDSA formation.

Methods

Eplet mismatch analysis was performed in a cohort of 125 pediatric KTR-donor pairs (2006-2018). We determined the prevalence of each eplet mismatch and quantified the percentage of exposed patients who developed dnDSA for each mismatched eplet.

Results

Recipient median age was 14 (IQR 8-17) years with a racial distribution of 42% Black, 48% Caucasian, and 5.6% Middle-Eastern

SUBMITTER: Charnaya O 

PROVIDER: S-EPMC8602732 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature