Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research.

ABSTRACT:

Purpose

Widely used cone beam computed tomography (CBCT)-guided irradiators in preclinical radiation research are limited to localize soft tissue target because of low imaging contrast. Knowledge of target volume is a fundamental need for radiation therapy (RT). Without such information to guide radiation, normal tissue can be overirradiated, introducing experimental uncertainties. This led us to develop high-contrast quantitative bioluminescence tomography (QBLT) for guidance. The use of a 3-dimensional bioluminescence signal, related to cell viability, for preclinical radiation research is one step toward biology-guided RT.

Methods and materials

Our QBLT system enables multiprojection and multispectral bioluminescence imaging to maximize input data for the tomographic reco

SUBMITTER: Xu X 

PROVIDER: S-EPMC8602741 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature