New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).

ABSTRACT:

Introduction

Acute Graft-versus-Host Disease (GVHD) is the major toxicity of allogeneic hematopoietic cell transplantation (HCT). Systemic steroids are the standard primary treatment but only half of the patients will respond completely and the survival of steroid-refractory patients is poor. The gastrointestinal (GI) tract is a key target organ that usually determines a patient's response to therapy.

Areas covered

This review summarizes the use of clinical grading systems and biomarkers in GVHD treatment and highlights pathophysiologic phases of acute GVHD as context for the mechanisms of action and therapeutic targets of various approaches. We reviewed >100 publications and performed a search of ongoing, current clinical trials on the emerging therapeutic targets for proph

SUBMITTER: Choe H 

PROVIDER: S-EPMC8602762 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature