Sex and dose-dependent antinociceptive effects of the JNK (c-Jun N-terminal kinase) inhibitor SU 3327 are mediated by CB₂ receptors in female, and CB₁/CB₂ receptors in male mice in an inflammatory pain model.

ABSTRACT: Activation of c-Jun N-terminal kinases (JNKs) has been implicated in the development and persistence of inflammatory and neuropathic pain in animal models. Moreover, JNKs have been involved in the maintenance of chronic pain, as well as development of tolerance to antinociceptive agents in the opioid and cannabinoid class of compounds. In this study, we evaluated the antinociceptive effects of the JNK inhibitor SU 3327 (0.3-30 mg/kg) in the formalin pain model with an emphasis on the sex-specific actions of this compound. In wild-type C57BL6J mice, SU 3327 produced strong antinociceptive effects in the formalin pain model which were mediated by CB₂ receptors in females, and both CB₁ and CB₂ receptors in males. SU 3327 at a dose of 10 mg/kg produced antinoci

SUBMITTER: Blanton HL 

PROVIDER: S-EPMC8602765 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature