Expression of Immune Related Genes and Possible Regulatory Mechanisms in Alzheimer's Disease.

ABSTRACT: Immune infiltration of peripheral natural killer (NK) cells in the brain has been observed in Alzheimer's disease (AD). Immunity-related genes (IRGs) play an essential role in immune infiltration; however, the expression of IRGs and possible regulatory mechanisms involved in AD remain unclear. The peripheral blood mononuclear cells (PBMCs) single-cell RNA (scRNA) sequencing data from patients with AD were analyzed and PBMCs obtained from the ImmPort database were screened for cluster marker genes. IRG activity was calculated using the AUCell package. A bulk sequencing dataset of AD brain tissues was analyzed to explore common IRGs between PBMCs and the brain. Relevant regulatory transcription factors (TFs) were identified from the Human TFDB database. The protein-protein interaction networ

SUBMITTER: Lu Y 

PROVIDER: S-EPMC8602845 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature