Trends in prescribing pattern of opioid and benzodiazepine substitutes among Medicare part D beneficiaries from 2013 to 2018: a retrospective study.

ABSTRACT:

Objective

Opioid and benzodiazepine co-prescribing is associated with a substantial increase in opioid overdose deaths. In this study, we examine the prescribing trends of substitutes of opioids and benzodiazepines alone or in combination, compared with opioids and benzodiazepines.

Design

Retrospective cohort study.

Setting

Data were collected using a 20% national sample of Medicare beneficiaries from 2013 to 2018.

Participants

4.1-4.3 million enrollees each year from 2013 to 2018.

Intervention

None.

Primary outcome

We employ a generalised linear mixed models to calculate ORs for opioid use, benzodiazepine or Z-drug (benzos/Z-drugs) use, opioid/benzos/Z-drugs 30-day use, gabapentinoid use and (selective serotonin reuptake inhibitors (SSRI) and ser

SUBMITTER: Esechie A 

PROVIDER: S-EPMC8603279 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature