Inflammation mediates depression and generalized anxiety symptoms predicting executive function impairment after 18 years.

ABSTRACT:

Introduction

Scar theories propose that elevated depression and anxiety can predispose people to future decreased executive function (EF) via heightened inflammation across decades. However, more longitudinal (versus cross-sectional) research on this topic is needed.

Objective

We thus investigated if increased major depressive disorder (MDD), generalized anxiety disorder (GAD), and panic disorder (PD) severity predicted EF decrement 18 years later via heightened inflammation.

Method

Community-dwelling adults participated in this study. Time 1 (T1) MDD, GAD, and PD severity (Composite International Diagnostic Interview-Short Form), T2 inflammation (interleukin-6, C-reactive protein, and fibrinogen blood levels concentration), and T2 and T3 EF (Brief Test of Adult Cogni

SUBMITTER: Zainal NH 

PROVIDER: S-EPMC8603378 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature