Potential biomarkers of abnormal osseointegration of implants in type II diabetes mellitus.

ABSTRACT:

Background

Type II diabetes mellitus (T2DM) is an important risk factor for osseointegration of implants. The aim of this study was to explore key genes of T2DM affecting bone metabolism through bioinformatic analysis of published RNA sequencing data, identify potential biomarkers, and provide a reference for finding the molecular mechanism of abnormal osseointegration caused by T2DM.

Methods

We identified differentially expressed mRNAs and miRNAs from the Gene Expression Omnibus database using the R package 'limma' and analysed the predicted target genes using Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis and Gene Ontology analysis. At the same time, miRNA-mRNA interactions were explored using miRWalk 2.0.

Results

We constructed an miRNA-gene re

SUBMITTER: Wang L 

PROVIDER: S-EPMC8603511 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature