Facilitated cascade testing (FaCT): a randomized controlled trial.

ABSTRACT:

Background

Identifying mutation-carrying relatives of patients with hereditary cancer syndromes via cascade testing is an underused first step in primary cancer prevention. A feasibility study of facilitated genetic testing of at-risk relatives of patients with a known pathogenic mutation demonstrated encouraging uptake of cascade testing.

Primary objective

Our primary objective is to compare the proportion of genetic testing of identified first-degree relatives of probands with a confirmed BRCA1/2 mutation randomized to a facilitated cascade testing strategy versus standard of care, proband-mediated, information sharing.

Study hypothesis

We hypothesize that facilitated cascade testing will drive significantly higher uptake of genetic testing than the standard

SUBMITTER: Nitecki R 

PROVIDER: S-EPMC8603783 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature