Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations.

ABSTRACT: The interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural and compositional alterations in the gut microbiota of the SARS-CoV-2-infected group in comparison to non-infected controls. The gut microbiota composition of the SARS-CoV-2-infected individuals showed an increase in anti-inflammatory bacteria such as Faecalibacterium (p-value = 1.72 × 10^-6) and Bacteroides (p-value = 5.67 × 10^-8). We also revealed a higher relative abundance of the highly beneficial butyrate

SUBMITTER: Al Bataineh MT 

PROVIDER: S-EPMC8603808 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature