Resolution of hepatitis E virus infection in CD8+ T cell-depleted rhesus macaques.

ABSTRACT:

Background & aims

HEV is a significant cause of acute hepatitis globally. Some genotypes establish persistent infection when immunity is impaired. Adaptive immune mechanisms that mediate resolution of infection have not been identified. Herein, the requirement for CD8+ T cells to control HEV infection was assessed in rhesus macaques, a model of acute and persistent HEV infection in humans.

Methods

Rhesus macaques were untreated or treated with depleting anti-CD8α monoclonal antibodies before challenge with an HEV genotype (gt)3 isolate derived from a chronically infected human patient. HEV replication, alanine aminotransferase, anti-capsid antibody and HEV-specific CD4+ and CD8+ T cell responses were assessed after infection.

Results

HEV control in untreated macaques

SUBMITTER: Bremer W 

PROVIDER: S-EPMC8603813 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature