Interleukin 20 receptor A expression in colorectal cancer and its clinical significance.

ABSTRACT:

Background

Interleukin 20 receptor A (IL20RA) has been shown to play a role in the establishment and progression of multiple tumors. However, the expression of this protein in colorectal cancer (CRC) and its correlation with the clinicopathological parameters of CRC have remained unclear.

Methods

A total of 323 paraffin sections including CRC tissues and adjacent normal tissues after surgery were collected. IL20RA protein expression was detected by immunohistochemical staining. The difference expression of IL20RA mRNA between CRC and normal tissues was also explored in the Oncomine and GEO databases. In addition, the IL20RA-related differentially expressed genes were analyzed in TCGA database and enrichment analysis was conducted to explore the cell functions and pathways re

SUBMITTER: Liu R 

PROVIDER: S-EPMC8603834 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature