Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution.

ABSTRACT: The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. Volumetric analysis of cerebellar morphometry in magnetic resonance imaging studies suffers from insufficient resolution, and therefore has had limited impact on disease assessment. Automatic serial polarization-sensitive optical coherence tomography (as-PSOCT) is an emerging technique that offers the advantages of microscopic resolution and volumetric reconstruction of large-scale samples. In this study, we reconstructed multiple cubic centimeters of ex vivo human cerebellum tissue using as-PSOCT. The morphometric and optical properties of the cerebellar cortex across five subjects were quantified. While the molecular and granular layers exhibited similar mean thickness in the five subjects, t

SUBMITTER: Liu CJ 

PROVIDER: S-EPMC8603939 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature