Immune characterization of a Colombian family cluster with SARS-CoV-2 infection.

ABSTRACT:

Introduction

Immunological markers have been described during COVID-19 and persist after recovery. These immune markers are associated with clinical features among SARSCoV-2 infected individuals. Nevertheless, studies reporting a comprehensive analysis of the immune changes occurring during SARS-CoV-2 infection are still limited.

Objective

To evaluate the production of proinflammatory cytokines, the antibody response, and the phenotype and function of NK cells and T cells in a Colombian family cluster with SARS-CoV-2 infection.

Materials and methods

Proinflammatory cytokines were evaluated by RT-PCR and ELISA. The frequency, phenotype, and function of NK cells (cocultures with K562 cells) and T-cells (stimulated with spike/RdRp peptides) were assessed by flow cytometr

SUBMITTER: Aguilar-Jimenez W 

PROVIDER: S-EPMC8604040 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature