Prevalence of nodal involvement in rectal cancer after chemoradiotherapy.

ABSTRACT:

Background

The purpose of this study was to investigate the prevalence of ypN+ status according to ypT category in patients with locally advanced rectal cancer treated with chemoradiotherapy and total mesorectal excision, and to assess the impact of ypN+ on disease recurrence and survival by pooled analysis of individual-patient data.

Methods

Individual-patient data from 10 studies of chemoradiotherapy for rectal cancer were included. Pooled rates of ypN+ disease were calculated with 95 per cent confidence interval for each ypT category. Kaplan-Meier and Cox regression analyses were undertaken to assess influence of ypN status on 5-year disease-free survival (DFS) and overall survival (OS).

Results

Data on 1898 patients were included in the study. Median follow-up was

SUBMITTER: Haak HE 

PROVIDER: S-EPMC8604154 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature