Hydrogen sulfide donor protects against mechanical ventilation-induced atrophy and contractile dysfunction in the rat diaphragm.

ABSTRACT: Mechanical ventilation (MV) is a clinical tool providing adequate alveolar ventilation in patients that require respiratory support. Although a life-saving intervention for critically ill patients, prolonged MV results in the rapid development of inspiratory muscle weakness due to both diaphragmatic atrophy and contractile dysfunction; collectively known as "ventilator-induced diaphragm dysfunction" (VIDD). VIDD is a severe clinical problem because diaphragmatic weakness is a risk factor for difficulties in weaning patients from MV. Currently, no standard treatment to prevent VIDD exists. Nonetheless, growing evidence reveals that hydrogen sulfide (H₂ S) possesses cytoprotective properties capable of protecting skeletal muscles against several hallmarks of VIDD, including oxidat

SUBMITTER: Ichinoseki-Sekine N 

PROVIDER: S-EPMC8604213 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature