Effects of sedative psychotropic drugs combined with oxycodone on respiratory depression in the rat.

ABSTRACT: Following a decision to require label warnings for concurrent use of opioids and benzodiazepines and increased risk of respiratory depression and death, the US Food and Drug Administratioin (FDA) recognized that other sedative psychotropic drugs may be substituted for benzodiazepines and be used concurrently with opioids. In some cases, data on the ability of these alternatives to depress respiration alone or in conjunction with an opioid are lacking. A nonclinical in vivo model was developed that could detect worsening respiratory depression when a benzodiazepine (diazepam) was used in combination with an opioid (oxycodone) compared to the opioid alone based on an increased arterial partial pressure of carbon dioxide (pCO₂ ). The current study used that model to assess the impa

SUBMITTER: Xu L 

PROVIDER: S-EPMC8604244 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature