An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness.

ABSTRACT: Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that the impact of antibiotics to prevent infection, multi-organ failure, and death in the ICU is less clear than their benefit on course of infection in the absence of organ dysfunction. We characterized here the compositional and metabolic changes of the gut microbiome induced by critical illness and antibiotics in a cohort of 75 individuals in conjunction with 2,180 gut microbiome samples representing 16 different diseases. We revealed an "infection-vulnerable" gut microbiome environment present only in critically ill treated with antibiotics (ICU⁺). Feeding of Caenorhabditis elegans with Bifidobacterium animalis and Lactobacillus crispatus, species that expand

SUBMITTER: Marfil-Sanchez A 

PROVIDER: S-EPMC8604395 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature