Multi-pronged research on endemic chronic kidney disease of unknown etiology in Sri Lanka: a systematic review.

ABSTRACT: Increasing prevalence of endemic chronic kidney disease of unknown etiology (CKDu) in Sri Lanka is a major health problem since the 1990s. Despite numerous studies on CKDu, research groups have been unable to develop a comprehensive approach to mitigate the disorder, and thereby to identify research gaps. We conducted a systematic literature review of 119 publications on CKDu in Sri Lanka from Pubmed, Google Scholar, and Scopus, published until end September 2020. A higher CKDu prevalence in the working population of the North Central Province was reported with recent studies indicating patients from non-endemic regions as well. A majority were etiological studies that recorded conflicting and inconclusive evidence on CKDu etiology. Studies on clinico-pathological, diagnostic, biochemical,

SUBMITTER: Arambegedara D 

PROVIDER: S-EPMC8604553 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature