Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic.

ABSTRACT: Neurosurgery as one of the most technologically demanding medical fields rapidly adapts the newest developments from multiple scientific disciplines for treating brain tumors. Despite half a century of clinical trials, survival for brain primary tumors such as glioblastoma (GBM), the most common primary brain cancer, or rare ones including primary central nervous system lymphoma (PCNSL), is dismal. Cancer therapy and research have currently shifted toward targeted approaches, and personalized therapies. The orchestration of novel and effective blood-brain barrier (BBB) drug delivery approaches, targeting of cancer cells and regulating tumor microenvironment including the immune system are the key themes of this review. As the global pandemic due to SARS-CoV-2 virus continues, neurosurgery

SUBMITTER: Ljubimov VA 

PROVIDER: S-EPMC8604570 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature